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Selegiline patch doesn't alter sexual function
Thursday, Jan. 17, 2008; 3:27 PM
NEW YORK (Reuters Health) - Short-term treatment with selegiline, administered through a skin patch, or "transdermal system," does not impair sexual function in patients with major depressive disorder, the results of a clinical review published in the Journal of Clinical Psychiatry suggest.
Selegiline, sold in the United States under the trade name Emsam, is a monoamine oxidase type B inhibitor used to treat patients with major depressive disorder.
According to Dr. Anita H. Clayton, of the University of Virginia Health System, Charlottesville, and colleagues, the product labeling indicates that the rate of reported sexual side effects of antidepressants is relatively low. However, recent studies "using patient-completed or clinician-administered questionnaires have found rates ranging from 22 percent to 73 percent."
A standardized patient-rated questionnaire was used to assess sexual interest, arousal, maintenance of interest, orgasm and satisfaction. The patients were an average of 42 years old and 62 percent were female.
Estimates of differences between transdermal selegiline and placebo revealed a trend, which was not statistically significant, toward a positive treatment effect of STS on most areas of sexual function.
A statistically significant positive effect was observed for women in the areas of interest in sex, maintaining interest during sex and satisfaction. No differences between selegiline and placebo were found for men.
Further analysis was conducted to separate the direct effects from indirect effects of selegiline on sexual function via improvements in depressive symptoms.
They found no differences between transdermal selegiline and placebo, which suggests the drug did not worsen any areas of sexual function in men or women after accounting for improvements in depression, Clayton's team reports.
SOURCE: Journal of Clinical Psychiatry, December 2008.